SimThyr, developed by Johannes W. Dietrich, is a powerful software for modeling and analyzing thyroid homeostasis. This Windows 7 compatible software offers numerous features including customizable parameter settings, various visualization options, and advanced mathematical models. With a user-friendly interface and comprehensive help system, researchers and clinicians alike can benefit from SimThyr's capabilities. Try it today and discover the full potential of thyroid simulation.

Thyroid hormones play an essential role for metabolism, growth and differentiation. Therefore, exact regulation of thyroid hormone levels is vital for most organisms. Although the principles of thyrotropic feedback control have been described decades ago we still have not yet gained comprehensive understanding of its dynamics.

Recently, significant progress has been made with mathematical modelling of thyroid homeostasis. However, due to nonlinear interactions, these cybernetic modells cannot simultaneously describe static and dynamic behaviour. This gap may be filled with computer simulations that additionally facilitate an intuitive insight into the dynamics of thyrotropic feedback.

SimThyr is a simulation program for the pituitary thyroid feedback control that is based on a parametrically isomorphic model of the overall system. Applications of this program cover research, including development of hypotheses, and education of students in biology and medicine, nurses and patients.

This is a free application that is offered on the base of a BSD licence. Binaries are available for Mac OS, Mac OS X and Windows, sourcecode requires THINK Pascal (for Mac OS Classic) or Lazarus/Free Pascal (for Mac OS X, Windows and Linux).

New Release
Milestone 4.0 (Merlion):
Major re-write of simulator engine, addition of null isocline plots, enhanced data export options and model annotations
4.0: First version of SimThyr 4 featuring nullcline plots, numeric export options and support for MIRIAM-compliant models (SVN commits 262 to 288 and 296 to 401, 13-IV-2017).
[ SimThyr release history ]

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